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This enzyme breaks down cGMP, a substance that induces smooth muscles to relax. Blocking PDE-5 means increased levels of cGMP within the smooth muscles which promotes muscle relaxation and vasodilation a widening of blood vessels. High levels of PDE-5 are found in the penis, lungs, and retina. PDE-5 is also found throughout the body within the smooth muscle cells of blood vessels and muscles. Sildenafil Citrate belongs to the class of medicines known as PDE-5 inhibitors.
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Sildenafil Citrate increases blood flow to the penis following sexual stimulation. It does this by blocking the enzyme responsible for the breakdown of cGMP.
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